Na,K-ATPase α2 and Ncx4a regulate zebrafish left-right patterning
نویسندگان
چکیده
منابع مشابه
Left-right patterning: conserved and divergent mechanisms.
The left-right (LR) asymmetry of visceral organs is fundamental to their function and position within the body. Over the past decade or so, the molecular mechanisms underlying the establishment of such LR asymmetry have been revealed in many vertebrate and invertebrate model organisms. These studies have identified a gene network that contributes to this process and is highly conserved from sea...
متن کاملLeft Right Patterning, Evolution and Cardiac Development
Many aspects of heart development are determined by the left right axis and as a result several congenital diseases have their origins in aberrant left-right patterning. Establishment of this axis occurs early in embryogenesis before formation of the linear heart tube yet impacts upon much later morphogenetic events. In this review I discuss the differing mechanisms by which left-right polarity...
متن کاملCelf1 regulation of dmrt2a is required for somite symmetry and left-right patterning during zebrafish development.
RNA-binding proteins (RBPs) bind to numerous and diverse mRNAs to control gene expression post-transcriptionally, although the in vivo functions of specific RBP-mRNA interactions remain largely unknown. Here, we show that an RBP named Cugbp, Elav-like family member 1 (Celf1) controls expression of a gene named doublesex and mab-3 related transcription factor 2a (dmrt2a), which is essential for ...
متن کاملBCL6 and BCoR gang up on Notch to regulate left-right patterning.
In this issue of Developmental Cell, Sakano et al. describe a novel mechanism of how a key lymphocyte transcription factor crosstalks to Notch signaling during embryonic development and thereby selectively inhibits Notch-activated target genes to allow proper left-right patterning.
متن کاملS10-05 Linking organ formation to left–right patterning in the embryonic zebrafish
Handedness in plant growth may be most familiar to us as tendrils of twinning plants, which generally form consistent rightor left-handed helices as they climb. Also, the petals of several species are arranged like fan blades that twist in the same direction. To unravel molecular components and cellular determinants of handedness and anisotropic growth, we screened seedlings of Arabidopsis thal...
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ژورنال
عنوان ژورنال: Development
سال: 2007
ISSN: 1477-9129,0950-1991
DOI: 10.1242/dev.02851